Harold Soyinka (David Oyelowo) is an average businessman who works for Cannabax Technologies Inc, a company that has developed the "Weed Pill", medical marijuana that has been simplified into a pill. Harold's bosses, Elaine Markinson (Charlize Theron) and Richard Rusk (Joel Edgerton), send him to Mexico to handle the manufacturing of the product, but while out partying he ends up getting kidnapped by the cartel, which holds a grudge against Harold's bosses and their company. Richard hires a professional named Mitch (Sharlto Copley) to safely get Harold out of harm's way, only for the two to end up having to survive one outrageous situation after another.

The film is directed by Nash Edgerton and written by Anthony Tambakis and Matthew Stone. This is an Amazon Studios production.